Located directly east of Manila., it is known for the Ortigas Center, a commercial and business center that is also shared with the city of Pasig. Notable institutions and establishments in the city include the Asian Development Bank, the headquarters of Banco De Oro and San Miguel Corporation and shopping malls like Shangri-La Plaza and SM Megamall.
Mandaluyong lies on a heart-shaped 11.06 square kilometres (4.27 sq mi) of land, 7 kilometres (4.3 mi) southeast of Manila and 8 kilometres (5.0 mi) west of Pasig. To the south lies Makati, to the northwest, San Juan, and to the northeast, Quezon City. Thus Mandaluyong is located at the center of Metro Manila.